I was having between 200-300 concurrent connections and people connecting were doing quite a lot of indirect seeks on the disks, especially with bad formatted media files (mp4) in which instead of interleaving the audio and video tracks, there were put in a totally separate file regions.
The poor disk didn't last for more than 3 weeks. I was doing VOD on a production server using SSD as storage. I personally killed an SSD drive but not with this schema. Yes, this is very important piece of information.